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c/reconstitution·submitted 1 year ago by u/aleksi_lehtinen

[Question] mg/mL — what am I missing here

Questionbranch of 11 comments

Slightly embarrassed to be asking this, but: mg/mL — what am I missing here. Bacteriostatic water contains benzyl alcohol as a preservative, which is what makes repeated entry into the same vial reasonable. Plain sterile water has no preservative. If your calculation produces a fraction of a unit, the concentration…

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11 comments, started 1 year ago
u/ines_lindqvist184 points·1 year ago

Agreed on the swirl. There is no reason to shake it and a good reason not to.

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u/emil_wojcik98 points·1 year ago

Disagree with the "more water is safer" framing. It is not safer, it is just a different number to divide by.

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u/gradient_goblin97 points·1 year ago

Pushback on the syringe advice: a U-100 barrel reads units of volume. Calling them "doses" is how the confusion starts.

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u/rosa_mensah34 points·1 year ago

Cosigning the round-number approach. Reconstituting to something awkward is how you end up drawing 27.5 units at six in the morning.

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u/katrin_marchetti146 points·1 year ago

aim the stream at the glass wall, not at the cake

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u/nabila_espinoza90 points·1 year ago

Are you accounting for the powder volume, or is that where the confusion is?

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u/viktor_erdogan127 points·1 year ago

write the concentration on the vial in marker, that is the whole post

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u/india_generic_g93 points·1 year ago

Wrote the date on the vial as well as the concentration after losing track of which one was opened first.

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u/rosa_mensah116 points·1 year ago

Reconstituted at 1mL when I meant to use a different volume. Caught it because the units looked wrong on the barrel. Now I write 5mg/mL on the glass before I put the cap back.

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u/viktor_kirchner95 points·1 year ago

Careful — that arithmetic is wrong. 15mg in 3mL is 5mg/mL, so 2.5mg draws to 50 units, not what you wrote.

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u/bruno_dumitru57 points·1 year ago

What concentration did you actually reconstitute at, rather than what did you intend to?

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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