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c/reconstitution·submitted 2 years ago by u/emeka_delgado

[Question] how do you actually verify insulin syringe

Questionbranch of 10 comments

Asking properly rather than in a comment on somebody else’s thread: how do you actually verify insulin syringe. Shook the first vial because nobody told me not to. It was fine, but I have swirled every one since. Wrote the date on the vial as well as the concentration after losing track of which one was opened first.…

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10 comments, started 2 years ago
u/clara_weiss260 points·2 years ago

Careful — that arithmetic is wrong. 5mg in 3mL is 1.67mg/mL, so 0.25mg draws to 15 units, not what you wrote.

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u/aleksi_lehtinen-24 points·2 years ago

Asked CPC what volume they reconstitute to for their own stability testing and they answered in one line. Useful thing to know.

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u/reflux_report175 points·2 years ago

The lyophilised cake displaces a small volume, so the true concentration is very slightly lower than the arithmetic suggests. It is a fraction of a percent and it is dwarfed by fill tolerance.

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u/iman_falk66 points·2 years ago

The arithmetic in full: concentration is mass over volume, so 20mg into 2mL gives 10mg/mL. A U-100 syringe is graduated at 100 units per millilitre, so 2.5mg is 2.5 divided by 10 millilitres, which is 25 units.

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u/andres_sorensen15 points·2 years ago

Spent 24 weeks confused about this until somebody drew the table for me. 10mg, 2mL, 5mg/mL, 0.75mg is 15 units. That is the whole thing.

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u/wanjiru_varga4 points·2 years ago

Reconstituted at 3mL when I meant to use a different volume. Caught it because the units looked wrong on the barrel. Now I write 10mg/mL on the glass before I put the cap back.

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u/cardio_endpoint_c0 points·2 years ago

This. Showing the working is the fastest way for somebody else to spot the mistake.

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u/emeka_delgadoOP29 points·2 years ago

I keep a laminated card in the drawer with the arithmetic on it. Looks ridiculous. Has never once let me draw the wrong volume.

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u/runa_cabrera15 points·2 years ago·edited

I keep a laminated card in the drawer with the arithmetic on it.

Disagreeing with this line only: adding more water is not a safety margin, it is a different divisor.

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u/tuva_kirchner7 points·2 years ago

Yes, and the dead-space point is worth repeating: it is small, it is real, and it is the same for every draw.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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