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c/reconstitution·submitted 2 years ago by u/reflux_report

[Meta] proposal — a flair for bacteriostatic water posts

Discussionbranch of 11 comments

Putting this to the board: proposal — a flair for bacteriostatic water posts. Aim the stream down the wall of the vial rather than into the cake. Reconstitution is a solubility problem, not a mixing problem, and mechanical shear does nothing helpful. The lyophilised cake displaces a small volume, so the true…

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11 comments, started 2 years ago
u/swirl_dont_shakereconstitution92 points·2 years ago

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

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u/reflux_reportOP50 points·2 years ago

Small fix — a U-100 syringe is 100 units per mL. If yours is marked differently it is not U-100 and the whole calculation changes.

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u/gradient_goblin-23 points·2 years ago

How many mg in the vial and how many mL are you adding?

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u/reflux_reportOP47 points·2 years ago

What is written on the vial right now?

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u/emil_wojcik38 points·2 years ago

That only works if the fill weight is exactly the label weight, and it usually is not exactly anything.

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u/gradient_goblin25 points·2 years ago

Right — the volume you add is the only variable you control here, and the cake does not change it meaningfully.

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u/reflux_reportOP14 points·2 years ago

That is sterile water, not bacteriostatic. Same appearance, different product, and it matters for a multi-draw vial.

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u/reflux_report8 points·2 years ago·edited

Yes, and the dead-space point is worth repeating: it is small, it is real, and it is the same for every draw.

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u/mateusz_achebe6 points·2 years ago

the powder cake sits at the bottom, the volume you add is the volume that counts

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[removed]4 points·2 years ago

[removed by moderator]

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u/swirl_dont_shakereconstitution73 points·2 years ago

if the maths gives you a fraction of a unit, change the concentration

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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