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c/reconstitution·submitted 8 months ago by u/vito_beaulieu

dead space is the most under-discussed thing on this board

Mathbranch of 8 comments

dead space is the most under-discussed thing on this board, and I am aware this is a minority view on this board. The whole calculation, once, with real numbers. You have a 5mg vial. You add 3mL of bacteriostatic water. Concentration is mass over volume: 1.67mg/mL. A U-100 insulin syringe is graduated at 100 units…

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8 comments, started 8 months ago
u/sleep_apnea_sam52 points·8 months ago

Why "more water" keeps confusing people, including me for a month.

The vial contains a fixed amount of peptide. Water changes nothing about that amount. What it changes is concentration, and concentration is the divisor between the dose you want and the volume you draw.

So doubling the water halves the concentration and doubles the units for the same dose. Nothing is diluted in any sense that matters; you are simply reading a bigger number off the same barrel. Pick the water volume that puts your usual dose on a whole number of units and life gets easier.

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u/units_not_mgsyringe math27 points·8 months ago

Bacteriostatic or plain sterile water?

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u/vito_beaulieuOP14 points·8 months ago

That is sterile water, not bacteriostatic. Same appearance, different product, and it matters for a multi-draw vial.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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