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c/reconstitution·posted 10 months ago by u/nadia_kjaer

[Discussion] the dead space advice in here is 3 years out of date

Discussion Slow Clap ×5

Thinking out loud about this: the dead space advice in here is 3 years out of date.

The relevant figures are 3 years, and they come from the same log I have kept the whole time.

The arithmetic in full: concentration is mass over volume, so 15mg into 1mL gives 15mg/mL. A U-100 syringe is graduated at 100 units per millilitre, so 1.5mg is 1.5 divided by 15 millilitres, which is 10 units.

Started reconstituting everything to a round concentration and the six-in-the-morning error rate went to zero.

Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.

651 up / 192 down77% upvoted15 commentsid 15s17o5 Sep 2025

15 comments

15 in this archive, depth 6

best — the order this archive was captured in

u/emeka_delgado53 points·10 months ago

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

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u/marta_weiss36 points·10 months ago

I keep a laminated card in the drawer with the arithmetic on it. Looks ridiculous. Has never once let me draw the wrong volume.

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u/escrow_evangelist42 points·10 months ago

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions fo

Disagreeing with this line only: adding more water is not a safety margin, it is a different divisor.

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u/spain_receta-23 points·10 months ago

The whole calculation, once, with real numbers.

You have a 5mg vial. You add 1mL of bacteriostatic water. Concentration is mass over volume: 5mg/mL. A U-100 insulin syringe is graduated at 100 units per millilitre, so one unit is 0.01mL.

To draw 5mg you need 5 divided by 5 millilitres, which is 100 units on the barrel. Write "5mg/mL" on the vial in marker before you put it away, and you never have to do this again for that vial.

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u/ines_lindqvist39 points·10 months ago

Same. I got this wrong once, caught it because the units looked absurd, and have written on every vial since.

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u/saskia_mwangi22 points·10 months ago

How many mg in the vial and how many mL are you adding?

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u/sigrid_kaufmann26 points·10 months ago

Wrote the date on the vial as well as the concentration after losing track of which one was opened first.

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u/reflux_report11 points·10 months ago

Yes. Writing 10mg/mL on the vial takes four seconds and removes the entire class of error this board exists to fix.

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u/aleksi_lehtinen18 points·10 months ago·edited

What is written on the vial right now?

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u/nadia_kjaerOP11 points·10 months ago

Did the maths give you a whole number of units, or a fraction?

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u/andres_sorensen5 points·10 months ago

10mg into 1mL is 10mg/mL, and 0.5mg of that is 5 units

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u/nadia_kjaerOP0 points·10 months ago

Bacteriostatic or plain sterile water?

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u/honest_syringe_20251 point·10 months ago

Is that a U-100 syringe? The barrel markings change the answer completely.

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u/emil_zamora17 points·10 months ago

label the vial with the date as well as the concentration

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u/nadia_kjaerOP6 points·10 months ago

Are you accounting for the powder volume, or is that where the confusion is?

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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