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c/reconstitution·posted 1 months ago by u/RetaAndRegret2

why does nobody talk about bacteriostatic water

Math Slow Clap ×3 Sourced ×2

why does nobody talk about bacteriostatic water. I would rather ask a basic question now than get this wrong quietly for two months.

Adding more water does not change how much peptide is in the vial. It changes the concentration, which changes the volume you draw for the same amount. That is the entire relationship.

Bacteriostatic water contains benzyl alcohol as a preservative, which is what makes repeated entry into the same vial reasonable. Plain sterile water has no preservative.

The lyophilised cake displaces a small volume, so the true concentration is very slightly lower than the arithmetic suggests. It is a fraction of a percent and it is dwarfed by fill tolerance.

Tell me where this is wrong. That is the useful part of posting it.

1,823 up / 150 down92% upvoted22 commentsid 14ohmi9 Jun 2026

22 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/saskia_mwangi120 points·1 months ago·edited

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

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u/karim_ilunga117 points·1 months ago

What concentration did you actually reconstitute at, rather than what did you intend to?

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u/freya_onwuka140 points·1 months ago

Agreed on the swirl. There is no reason to shake it and a good reason not to.

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u/ahmed_rasmussen0 points·1 months ago

What concentration did you actually reconstitute at, rather than what did you intend to?

Adding one thing — put the date on the label too. Concentration plus date and you can never mix two vials up.

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u/wanjiru_varga78 points·1 months ago

Careful — that arithmetic is wrong. 5mg in 2mL is 2.5mg/mL, so 1mg draws to 40 units, not what you wrote.

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u/rina_bergstrom-33 points·1 months ago

Show the arithmetic — where did the unit figure come from?

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u/gradient_goblin1 point·1 months ago

bacteriostatic water has the preservative, sterile water does not

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u/yusuf_nakamura1 point·1 months ago

a U-100 syringe reads 100 units to the millilitre, every time

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u/piotr_bruun1 point·1 months ago

write the concentration on the vial in marker, that is the whole post

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u/emil_wojcik-48 points·1 months ago

Show the arithmetic — where did the unit figure come from?

Disagreeing with this line only: adding more water is not a safety margin, it is a different divisor.

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u/aleksi_lehtinen26 points·1 months ago

Yes, and the dead-space point is worth repeating: it is small, it is real, and it is the same for every draw.

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u/emil_okwuosa21 points·1 months ago

That is sterile water, not bacteriostatic. Same appearance, different product, and it matters for a multi-draw vial.

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u/kenji_kimani9 points·1 months ago

swirl, never shake

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u/elin_ferrari7 points·1 months ago

Pushback on the syringe advice: a U-100 barrel reads units of volume. Calling them "doses" is how the confusion starts.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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