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c/reconstitution·submitted 1 year ago by u/batch_number_bertie

[Question] reconstitution — what am I missing here

Questionbranch of 7 comments

reconstitution — what am I missing here. If this has been answered properly somewhere, link me and I will delete. The dead space question sent me down a rabbit hole for a week. It is a fraction of a unit and it is the same every draw. Spent 14 weeks confused about this until somebody drew the table for me. 10mg, 3mL,…

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7 comments, started 1 year ago
u/emil_zamora43 points·1 year ago

What is written on the vial right now?

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u/ines_lindqvist18 points·1 year ago

The arithmetic in full: concentration is mass over volume, so 5mg into 1mL gives 5mg/mL. A U-100 syringe is graduated at 100 units per millilitre, so 2mg is 2 divided by 5 millilitres, which is 40 units.

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u/cardio_endpoint_c10 points·1 year ago

label the vial with the date as well as the concentration

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u/arto_falk10 points·1 year ago

Small fix — a U-100 syringe is 100 units per mL. If yours is marked differently it is not U-100 and the whole calculation changes.

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u/runa_cabrera7 points·1 year ago

more water is not more drug, it is the same drug in a bigger volume

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u/batch_number_bertieOPvetting0 points·1 year ago

Is that a U-100 syringe? The barrel markings change the answer completely.

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u/india_generic_g1 point·1 year ago

I would not round that figure. At 20mg/mL a rounding error of two units is a real fraction of the intended amount.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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