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c/orforglipron·submitted 10 months ago by u/yannick_salinas

what would you tell week-1 you about ACHIEVE

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what would you tell week-1 you about ACHIEVE. I would rather ask a basic question now than get this wrong quietly for two months. Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can be formulated as a conventional…

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8 comments, started 10 months ago
u/lina_bruun26 points·10 months ago

It is a non-peptide small-molecule agonist at the GLP-1 receptor. That is a substantial medicinal chemistry achievement: getting a small molecule to activate a receptor evolved for a peptide ligand.

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u/yannick_salinasOP18 points·10 months ago

What analytical method was used — this is not the usual peptide assay question?

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u/enzo_ferrari4 points·10 months ago

Cosigning on daily dosing. It changes the exposure profile and it changes adherence, in both directions.

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u/lukas_delgado5 points·10 months ago

Nothing containing this compound is approved by any regulator, and research-use-only material is not approved for human use.

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u/ewan_hovland17 points·10 months ago

Spent an evening reading about small-molecule agonism at a peptide receptor. Genuinely interesting engineering.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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