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c/orforglipron·submitted 1 year ago by u/search_before_post

how much of what we believe about ACHIEVE actually comes from ATTAIN threads

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how much of what we believe about ACHIEVE actually comes from ATTAIN threads. I would rather ask a basic question now than get this wrong quietly for two months. Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can…

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6 comments, started 1 year ago
u/greta_nilsen5 points·1 year ago

small molecule, not a peptide, and that changes everything about it

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u/paloma_stanescu7 points·1 year ago

do not assume reconstitution intuitions apply, there is nothing to reconstitute

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u/piotr_bruun0 points·1 year ago

Milligram-for-milligram comparison with an injectable peptide is not meaningful and I should not have made it.

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u/viktor_laurent4 points·1 year ago

Small fix — the two programme names got swapped upthread and it changes which population the figure came from.

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u/discount_math_dm2 points·1 year ago

Agreed that phase 3 is where the comparison becomes fair. Everything before it is inference.

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u/joaquin_trevino1 point·1 year ago

Not convinced. Oral semaglutide is a peptide formulated with an absorption enhancer; the comparison you are making does not hold.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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