why does nobody talk about ACHIEVE
why does nobody talk about ACHIEVE — that is what I am asking, and I have already read the wiki twice.
Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.
Nothing containing this compound is approved by any regulator, and research-use-only material is not approved for human use.
Assumed the peptide purity conversations transferred and they do not. Different analytical problem entirely.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
Oral semaglutide is a peptide co-formulated with an absorption enhancer and carries food and water timing requirements. A small molecule does not have that constraint, which is the practical distinction.
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nothing containing this is approved anywhere and research material is not for human use
the tolerability profile reads broadly similar to the class
Has anyone here seen independent identity testing on this?
Left up. It is careful about what is peptide and what is not, which is more than most threads here manage.
the manufacturing story is genuinely different from the injectables
Small fix — the two programme names got swapped upthread and it changes which population the figure came from.
daily dosing changes adherence in both directions
Push back: daily dosing is not automatically better adherence. It is a different failure mode, not a solved problem.
no food and water restrictions is the practical difference people care about
Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can be formulated as a conventional tablet.
Is that from the publication or the press release?
Milligram-for-milligram comparison with an injectable peptide is not meaningful and I should not have made it.
daily dosing, not weekly, so the exposure profile is different
Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.
Careful — purity methods for peptides do not read across to a small molecule and the numbers are not equivalent.
Are you comparing doses across a small molecule and a peptide?
- 1Left up. It is careful about what is peptide and what is not, which is more…6 comments in this branch · started by u/incretin_ivy