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c/orforglipron·submitted 1 year ago by u/ice_pack_audit

reading oral GLP-1 threads from 2024 and half of it aged badly

Discussionbranch of 9 comments

Posting this as a discussion rather than a claim: reading oral GLP-1 threads from 2024 and half of it aged badly. What is actually known, and what is being assumed. Known: it is a small-molecule GLP-1 receptor agonist, dosed daily, with clinical programmes reporting in both obesity and type 2 diabetes. Its…

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9 comments, started 1 year ago
u/mateusz_mensah39 points·1 year ago

I would not assume the tolerability profile transfers exactly. Similar class effects, different exposure profile.

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u/ice_pack_auditOPcold chain45 points·1 year ago

Correcting myself: that was a phase 2 readout and I described it as phase 3.

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u/chidi_yilmaz34 points·1 year ago

ATTAIN and ACHIEVE are the programmes to keep straight

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u/purity_pedantanalytical8 points·1 year ago·edited

the manufacturing story is genuinely different from the injectables

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u/piotr_bruun10 points·1 year ago

oral semaglutide is a peptide with an absorption enhancer, this is not that

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u/meera_sandvik17 points·1 year ago

small molecule, not a peptide, and that changes everything about it

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u/discount_math_dm11 points·1 year ago

Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction.

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u/farid_kuipers35 points·1 year ago

no food and water restrictions is the practical difference people care about

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u/salma_almeida31 points·1 year ago

Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.

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