appetite: what the trials say vs what this community says
Posting this as a discussion rather than a claim: appetite: what the trials say vs what this community says. Tolerance to the gastric effect develops with continued exposure while the appetite effect largely persists. That single fact explains most of the "it settles but it still works" pattern the side-effect board…
Agreed that receptor distribution is the key to the side-effect map. It is not a mystery, it is anatomy.
receptor agonism is not the same as receptor activation in every tissue
Disagree. That is a preclinical finding in a rodent model and you are stating it as human pharmacology.
Not convinced by the linearity assumption. Dose-response in this class is not linear and the trials show it.
Read the primary paper after arguing about the summary for a fortnight. The discussion section said almost the opposite of what the thread had concluded.
Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.
Was completely wrong about the gastric emptying story in a thread here two years ago.
Disagreeing with this specific inference — that is a preclinical result being read as human pharmacology.
Agreed that receptor distribution is the key to the side-effect map.
This is the concept everything else on this board is downstream of.
Citations welcome and expected here — this is the one board where "source?" is a compliment.