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c/glp1science·submitted 1 year ago by u/split_dose_sceptic

someone explain appetite to me like I have not read a paper in years

Questionbranch of 6 comments

someone explain appetite to me like I have not read a paper in years, and I want the answer with the reasoning attached rather than just the conclusion. Glucose-dependent insulin secretion is why hypoglycaemia risk is low as monotherapy: the effect scales with glycaemia rather than acting unconditionally. The…

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6 comments, started 1 year ago
u/vikram_mbeki54 points·1 year ago·edited

Push back: a receptor being expressed in a tissue does not tell you the agonist reaches it at therapeutic exposure.

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u/enzo_danquah22 points·1 year ago

Cosigning on GIP. The genuinely interesting thing is that the biology is not settled and the clinical result is nonetheless robust.

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u/camila_lindqvist15 points·1 year ago

Careful — you have a plausible mechanism and no evidence that it is the operative one in the case you are describing.

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u/split_dose_scepticOP6 points·1 year ago

Which receptor arm are you attributing that to?

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u/not_my_main_nm4 points·1 year ago

gastric emptying slows, it does not stop

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u/rasmus_kimani5 points·1 year ago

Is there any human data on that mechanism yet?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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