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Single comment threadYou are looking at one branch of genuine question about sequence that I am slightly embarrassed to ask — 28 comments in the full submission. View in context.
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c/bpc157·submitted 1 year ago by u/tired_ledger_ftw

genuine question about sequence that I am slightly embarrassed to ask

Paperbranch of 10 comments

genuine question about sequence that I am slightly embarrassed to ask. I would rather ask a basic question now than get this wrong quietly for two months. Purity by area percent tells you the sample is homogeneous. Mass spectrometry tells you what the homogeneous thing is. For a short peptide, the second question is…

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10 comments, started 1 year ago
u/nikhil_lindqvist12 points·1 year ago

ask for the mass spectrum, not just the purity number

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u/elodie_yilmaz4 points·1 year ago

preclinical enthusiasm is not clinical evidence

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u/nils_ferreira3 points·1 year ago

preclinical enthusiasm is not clinical evidence

Adding the standing caveat — research material is not approved for human use, wherever you are.

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u/rosa_almeida2 points·1 year ago

Small fix — fifteen residues, not seventeen. The sequence is public and easy to check.

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u/katrin_girard2 points·1 year ago

stability in solution is the practical question nobody asks

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[deleted]1 point·1 year ago

[deleted]

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u/tired_ledger_ftwOP7 points·1 year ago

Which paper is that claim from, and was it in humans?

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u/throwaway_91823 points·1 year ago

Agreed — cheap to make is a double-edged fact and it explains a lot about this corner of the market.

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u/chain_confirm_cpayments4 points·1 year ago

This. Mass spectrometry for identity, not just an area percent, because a pure something-else is still something else.

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u/rasmus_kimani3 points·1 year ago

Careful. Regulatory status differs by jurisdiction and has changed; a confident global statement is going to be wrong somewhere.

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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