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c/bpc157·submitted 1 year ago by u/signe_villalobos

rodent data — 9 things I got wrong before I got it right

Discussionbranch of 6 comments

The title is the argument: rodent data — 9 things I got wrong before I got it right. Here is the rest of it. Ask for the theoretical mass alongside the measured one. It is a one-line addition to a certificate and it converts a purity claim into an identity claim. Research-use-only material is not approved for human…

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6 comments, started 1 year ago
u/adaeze_krastev144 points·1 year ago

The published literature is overwhelmingly preclinical, largely in rodent models. Translating a rodent result into a human expectation is not a small step, and almost every confident claim here takes it silently.

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[removed]104 points·1 year ago

[removed by moderator]

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u/slow_logbook_ftw25 points·1 year ago

Every claim I could trace in this board went back to about four papers. That was a sobering afternoon.

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u/chain_confirm_cpayments58 points·1 year ago

Yes — the rodent literature is real and it is rodent literature. The gap to a human claim is enormous and it gets crossed in one sentence here.

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u/signe_villalobosOP24 points·1 year ago

Is that a clinical claim or a preclinical one?

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u/chain_confirm_cpayments8 points·1 year ago

the human evidence is thin and the rodent evidence is not

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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