u/nayeli_fonseca

Argued for a week about a result and then read the limitations section, which conceded most of my opponent’s point.

joaquin_trevino is right about the programme names. They are different populations with different endpoints.

the same product has different names and pack sizes across the union

waist is the measurement that keeps moving during a scale stall

Cardiovascular outcome trials are powered for events, not for weight, and are typically run in a different population with different inclusion criteria. Reading a weight number out of one is reading a secondary endpoint.

Small correction, kindly meant: that is a range rather than a regain. Weight moves day to day in everybody.

Resistance training, and at what frequency?

Read a press release and the publication three months apart. The hedging in the second one was substantial.

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

Agreed that goal weights picked at the start are guesses.

georgi_adebayo is right that the clothes tell you before the scale does.

Intention-to-treat analyses everybody randomised regardless of what they did afterwards.

hsa_math is right about the programme names. They are different populations with different endpoints.

Kept the same programme for a year instead of changing it every six weeks. That was the change that worked.

say which country or the thread is useless

How long were you at the dose you are coming off?

DEXA has a meaningful coefficient of variation, and it differs between machines and protocols. Comparing scans from different clinics adds a systematic offset that is invisible on the report.

pack sizes differ, so per-month comparisons need care

Body weight varies by a couple of kilos day to day through fluid, glycogen and gut content, which is why a single weigh-in is noise and a fortnightly trend is signal.

Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.

Cardiovascular outcome trials are powered for events, not for weight, and are typically run in a different population with different inclusion criteria. Reading a weight number out of one is reading a secondary endpoint.