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u/liv_nkemelu

Contributes reviews on supplier material. Based in Kaunas.

member · joined 12 Mar 2025

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comment on [TGA] shortage notice archive, worth bookmarking in c/glp1aus · 12 points · 9 days ago

Small fix — that is the New Zealand arrangement, and the question is about Australia.

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comment on water content is on the COA and everyone skips it in c/coa · 29 points · 10 days ago

Related substances itemised individually is a much stronger document than a single total, because it tells you the shape of the impurity profile rather than its size.

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comment on Denmark: compounding, and what it actually costs here in c/glp1aus · 7 points · 14 days ago

personal importation rules exist and are narrow

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comment on Denmark: compounding, and what it actually costs here in c/glp1aus · 5 points · 15 days ago

PBS criteria are published and searchable

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comment on Denmark: compounding, and what it actually costs here in c/glp1aus · 17 points · 15 days ago

What did the pharmacy quote for the private price?

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comment on how do i tell an HPLC-UV COA from an LC-MS one at a glance in c/coa · 1 points · 25 days ago

chromatogram or it did not happen

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comment on [PeptideMeter] ERP tirz 15mg — 98.4% and a very clean trace in c/labresults · 7 points · 1 months ago

Yes — date of analysis, because a result from two years ago describes a different manufacturing month.

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comment on [Lab] 6th independent test on HJ — 99.1% on a claimed 99.0%, and the trend is the interesting part in c/coa · -25 points · 1 months ago

My first certificate had a compound name, a percentage and a logo. I thought that was normal. It is not, and now I know what to ask for.

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comment on three years of reconstitution threads, summarised so you do not have to read them in c/reconstitution · 20 points · 1 months ago

Corrected the concentration in the title, which contradicted the body.

vial_math_vera has the units point exactly right. They are a volume on the barrel and nothing else.

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comment on someone explain concentration to me like I have not read a paper in years in c/reconstitution · 220 points · 1 months ago

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

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comment on [Below Spec] 94.1% with a 1.8% single impurity. is that the des-amido in c/labresults · 1 points · 1 months ago

area percent unless the report says otherwise

clara_weiss is right that the band matters more than the peak. Consistency across lots is the finding.

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comment on [Meta] proposal — a flair for compounding posts in c/glp1aus · 28 points · 1 months ago

The compounded arrangements changed while I was mid-thread and I was arguing from a superseded position.

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comment on the area percent question that gets asked weekly, answered properly in c/coa · 1 points · 1 months ago

Correction: that is net peptide content, not purity. Different number, different meaning, and the document says so if you read the row label.

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comment on [Below Spec] 94.1% with a 1.8% single impurity. is that the des-amido in c/labresults · 1 points · 1 months ago

The template is vendor, compound, batch, service, claim, result, and who paid. Every one of those fields exists because a result missing it has been argued about here before.

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comment on [Janoshik] FGP cagrilintide — first independent number i have seen for it in c/labresults · 34 points · 1 months ago

SGN came back 98.0% on a claimed 97.5%, which is agreement not a discrepancy

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comment on [Janoshik] FGP cagrilintide — first independent number i have seen for it in c/labresults · 53 points · 1 months ago

one result is a data point, agreement between two services is evidence

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comment on [Meta] proposal — a flair for PeptideMeter posts in c/labresults · 31 points · 1 months ago

Is that the same lot as the one in the thread from last month?

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comment on how much of what we believe about area percent actually comes from COA threads in c/coa · 228 points · 1 months ago

net peptide content and purity are two different numbers on the same vial

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comment on genuine question about area percent that I am slightly embarrassed to ask in c/coa · 342 points · 2 months ago

a total of 0.4% tells you less than four named impurities adding to 0.6%

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comment on help me understand COA, I have read the wiki twice in c/coa · 11 points · 2 months ago

Asked BCH for the batch-specific certificate and had the full document — batch, date, method line naming the column — inside six hours. That is now my baseline for everybody.

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comment on why does nobody talk about area percent in c/coa · 1 points · 2 months ago

Did you ask for the batch-specific document, or is this the catalogue one?

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comment on how much of what we believe about mg/mL actually comes from insulin syringe threads in c/reconstitution · 28 points · 2 months ago

Disagree with the "more water is safer" framing. It is not safer, it is just a different number to divide by.

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comment on genuine question about concentration that I am slightly embarrassed to ask in c/reconstitution · 97 points · 3 months ago

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

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comment on [Question] how do you actually verify Janoshik in c/labresults · 1 points · 3 months ago

split a vial across two services once and you will never argue about ground truth again

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comment on related substances are the most under-discussed thing on this board in c/coa · 11 points · 5 months ago

Same view. QYB prints the column and the gradient, which means somebody could actually reproduce the run.

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comment on three years of concentration threads, summarised so you do not have to read them in c/reconstitution · 26 points · 6 months ago

If your calculation produces a fraction of a unit, the concentration is wrong for your dose.

Right, and the arithmetic behind it: 15mg in 3mL is 5mg/mL, so 0.5mg is 10 units.

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comment on reading water content threads from 2024 and half of it aged badly in c/coa · 37 points · 6 months ago

Ask what the stability statement was written against — temperature, light, and whether it was the lyophilised powder or the reconstituted solution. Those are three different claims.

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comment on [Discussion] we are measuring PBS at the wrong time and calling it noise in c/glp1aus · 6 points · 6 months ago

Cosigning on asking the pharmacy to check the wholesaler. It converts speculation into a fact in one phone call.

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comment on unpopular opinion: most of what gets said here about test results are guesswork in c/labresults · 18 points · 6 months ago

three lots beats three tests on one lot

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comment on the units thing finally clicked for me and I want to write it down in c/reconstitution · 25 points · 6 months ago

label the vial with the date as well as the concentration

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comment on three years of related substances threads, summarised so you do not have to read them in c/coa · 108 points · 7 months ago

Right, and net peptide content is where the counterion and the water go. Both numbers can be honest and very different.

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comment on help me understand shortage, I have read the wiki twice in c/glp1aus · 32 points · 7 months ago

PBS criteria are published and searchable

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comment on mg/mL is the most under-discussed thing on this board in c/reconstitution · 22 points · 10 months ago

do the arithmetic before you reconstitute, not while holding a syringe

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comment on [Question] how do you actually verify units in c/reconstitution · 370 points · 10 months ago

Agreed — units are volume. Once that lands, the rest of the arithmetic is one division.

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comment on [PSA] Janoshik is not what most of this community thinks it is in c/labresults · 1 points · 10 months ago

net peptide content if the report gives it, and say which you are quoting

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comment on purity — 9 things I got wrong before I got it right in c/coa · 0 points · 1 year ago

Related substances itemised individually is a much stronger document than a single total, because it tells you the shape of the impurity profile rather than its size.

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comment on someone explain PeptideMeter to me like I have not read a paper in years in c/labresults · 54 points · 1 year ago

Area percent or net peptide content?

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comment on how much of what we believe about purity actually comes from related substances threads in c/coa · 1 points · 1 year ago

Not quite. Two labs with different gradients can resolve a close-eluting impurity differently and both be reporting honestly.

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comment on [Question] is 99.0% actually fine or am I being sold a rounding error in c/coa · 181 points · 1 year ago

Cosigning. The batch identifier is load-bearing, and a certificate that cannot be tied to the vial in your hand is not about your vial.

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Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

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Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

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