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a pill with no food restrictions and no cold chain changes this entire site
Flairing this Speculation because that is what it is. Orforglipron is a small molecule, not a peptide. ATTAIN-1 and ACHIEVE-1 (both NEJM , 2025) reported the efficacy…
u/incretin_ivy
GIP/GLP-1 co-agonism is genuinely interesting pharmacology, separate from the weight story.
long-standing contributor · pharmacology · joined 8 Jul 2024
33,764post karma
41,322comment karma
18submissions
344comments
462
the actual pharmacokinetic case for twice-weekly splitting, and what it doesn’t prove
Splitting a weekly dose into two smaller injections comes up constantly so here's the actual PK argument, separated from the outcome-data question, which is a different…
401
[Explainer] half-life is 168 hours. that is why your injection day barely matters.
Every week somebody asks whether Tuesday is better than Sunday, and every week the answer is buried under anecdote. Semaglutide's terminal half-life is roughly 168…
182
cagrilintide — 17 things I got wrong before I got it right
cagrilintide — 17 things I got wrong before I got it right, which sounds obvious until you try to state the evidence for it. Dosing intuitions from the GLP-1 boards do…
475
[Discussion] the telehealth advice in here is 3 years out of date
the telehealth advice in here is 3 years out of date, and I am aware this is a minority view on this board. 3 years. Those are measured, not estimated, and not rounded…
0
the long term question that gets asked weekly, answered properly
the long term question that gets asked weekly, answered properly, and I am aware this is a minority view on this board. What maintenance actually looks like, from the…
1.6k
[Meta] the incretin rule is doing its job and people should stop complaining
the incretin rule is doing its job and people should stop complaining. Nothing about this affects the ranking maths, before anyone asks. GIP receptor biology is…
1k
[Meta] proposal — a flair for ACHIEVE posts
proposal — a flair for ACHIEVE posts. Disagreement welcome, but bring a concrete alternative wording. Why "oral" is doing two completely different jobs in the sentences…
1k
[Lab] 24th independent test on QSC — 98.4% on a claimed 98.0%, and the trend is the interesting part
Short version of the title, which is already short: 24th independent test on QSC — 98.4% on a claimed 98.0%, and the trend is the interesting part. Longer version…
2.6k
help me understand shortage list, I have read the wiki twice
Slightly embarrassed to be asking this, but: help me understand shortage list, I have read the wiki twice. The intake asked me three questions and none of them were…
3.4k
[Meta] proposal — a flair for Mounjaro posts
proposal — a flair for Mounjaro posts — posting the reasoning in public because a policy you cannot inspect is just a preference. On comparing yourself with the trial…
1.5k
why does nobody talk about mechanism
why does nobody talk about mechanism, and I want the answer with the reasoning attached rather than just the conclusion. Was completely wrong about the gastric emptying…
1.7k
reading 503A threads from 2024 and half of it aged badly
Something I keep coming back to: reading 503A threads from 2024 and half of it aged badly. The shortage list is the legal hinge: the permissions that allow certain…
2.4k
[Question] DEXA — what am I missing here
Trying to get a straight answer on this: DEXA — what am I missing here. How to make a DEXA comparison mean anything. Same machine, same clinic, same protocol. Same…
4.9k
[Results] 66 weeks on 15mg, full numbers, ask me anything boring
Six-word version is the title — 66 weeks on 15mg, full numbers, ask me anything boring — and the rest is context. 66 weeks and 15mg. Those are measured, not estimated,…
1.9k
[Meta] the pentadecapeptide rule is doing its job and people should stop complaining
the pentadecapeptide rule is doing its job and people should stop complaining — with the counter-argument included, because I find it fairly persuasive. Paid for…
0
23 months in and satiety is still the thing I get wrong
Here it is: 23 months in and satiety is still the thing I get wrong. One person, one log, no control group, so read it accordingly. The numbers the title promised,…
8.3k
week 19 check-in — 9kg down, early fullness manageable, one thing confusing me
week 19 check-in — 9kg down, early fullness manageable, one thing confusing me, logged the same way every week so the comparison is at least internally fair. The…