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Negative comment karma and completely at peace with it.

member · joined 6 Sep 2024

10,043post karma
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comment on [Vendor] JEEP six orders in, zero problems, and i am suspicious of my own luck in c/vendorvetting · 18 points · 2 days ago

fair. i was being reflexively cynical. withdrawn.

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comment on going up faster doesn’t get you there faster, it just gets you sicker faster in c/tirzepatide · 21 points · 2 days ago

ok that's a fairer version of the argument than the one I was reacting to, retracting some of that

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comment on [Below Spec] 61.2% on a vial i had already been using for six weeks in c/labresults · -28 points · 2 days ago

should have named the vendor immediately, people are ordering from them right now

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comment on [Explainer] half-life is 168 hours. that is why your injection day barely matters. in c/glp1science · 47 points · 2 days ago

...yes it is. leaving this up as a monument.

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comment on two labs, same vial, 98.1 and 96.4. both right? in c/hplc · -14 points · 2 days ago

if labs cannot agree the whole testing thing is pointless

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comment on [Vendor] JEEP six orders in, zero problems, and i am suspicious of my own luck in c/vendorvetting · -22 points · 2 days ago

six orders and no problems means you are not testing enough. everyone has bad batches, you just have not caught yours.

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comment on is 96.8% area% actually fine or am i being sold a rounding error in c/coa · 14 points · 2 days ago

i cannot, it is just what everyone says

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comment on [Seizure] third one in two years. the pattern is the carrier, not the country. in c/customs · -19 points · 2 days ago

just declare it as something else, everyone does this

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comment on going up faster doesn’t get you there faster, it just gets you sicker faster in c/tirzepatide · -19 points · 2 days ago

this is survivorship bias, plenty of people go up and it does resolve the stall, you're just assuming correlation was never causation for anyone

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comment on [Meta] how the ranking actually works, with the formula in c/meta · -14 points · 2 days ago

publishing the formula just tells people how to game it

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comment on amylin is not a GLP-1 and the co-agonism story is more interesting than the weight number in c/cagrilintide · -14 points · 3 days ago

it is all appetite suppression, the mechanism is trivia

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comment on nausea day 2 post-injection like clockwork, week 14, does it ever stop in c/sideeffects · -12 points · 3 days ago

if you still have nausea at week 14 you are on too high a dose

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comment on [Explainer] half-life is 168 hours. that is why your injection day barely matters. in c/glp1science · -15 points · 3 days ago

168 hours is wrong, it is 7 days

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comment on is 96.8% area% actually fine or am i being sold a rounding error in c/coa · -19 points · 3 days ago

anything under 98 is a scam, bin it

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comment on [Data] logger trace: 6 days transit, 41 hours above 8°C, powder was fine in c/coldchain · -16 points · 3 days ago

so cold shipping is a scam then, they should just send it in an envelope

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comment on [NHS] two years and four months on a tier 3 waiting list. timeline inside. in c/glp1uk · -13 points · 3 days ago

just go private, it is not that expensive

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comment on [Resolved] i accused QYB of a fake COA. i was wrong. correcting the record. in c/scamalerts · -19 points · 3 days ago

so the metadata check is useless then

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comment on [Concerning] ferritin 9. i was eating 1,100 calories and calling it discipline. in c/bloodwork · -15 points · 3 days ago

1100 calories is fine if you are not hungry, hunger is the signal

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comment on reconstituted vial left out for five hours — bin it or not in c/coldchain · -11 points · 3 days ago

bin it, why risk it

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comment on [Correction] you cannot report area% to two decimals off that baseline in c/hplc · -12 points · 3 days ago

this is pedantry with no consequence

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comment on [Medutest] SWB sema 10mg — 98.7%, and fourteen shipments with the cold chain intact in c/labresults · -13 points · 6 days ago

0.2 over the claim is within noise, so why is anyone treating it as a result at all

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comment on [Results] 14 months, 41kg, one boring spreadsheet, no photos by design in c/progresspics · 9 points · 12 days ago

Why this board is text only, since new members ask every week.

A photograph invites comparison on things nobody can control — lighting, posture, where you carry weight, what you looked like before any of this. Text invites description of what changed for you: the jacket, the stairs, the measurement, the month it took.

The result is a board where the posts are about people’s actual experience rather than about images, and where nobody is competing on the wrong axis. It was a deliberate choice, it has been challenged periodically, and every time it has been kept.

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comment on [Struggle] eight weeks, 2kg, doing everything right, and it is grinding me down in c/progresspics · 26 points · 23 days ago

Weighing under consistent conditions — same time, same state, same scale — removes most of the apparent variability people find distressing.

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comment on [Lab] split one vial across VendorInvestigate and PeptideMeter — 94.2% and 93.7% in c/hplc · 47 points · 1 months ago

Agreed, and it is why QST printing the column and gradient on the certificate is genuinely useful rather than decorative.

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comment on [Milestone] came off two blood pressure meds and one statin in c/progresspics · 90 points · 1 months ago

That is a waist measurement, not a weight, and the thread has been comparing them as though they were the same.

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comment on reading LC-MS threads from 2024 and half of it aged badly in c/hplc · 7 points · 1 months ago

Bought a second-hand instrument and learned more in six months of fixing it than in three years of reading traces.

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comment on [Question] how do you actually verify LC-MS in c/hplc · 36 points · 2 months ago

Why two honest labs report different numbers on the same vial.

Start with the gradient. A shallower slope holds compounds on the column longer and usually separates close-eluting species better. A steeper one gets you a faster run and a fatter peak. If a related substance elutes near the main peak, one method resolves it and reports it separately, the other absorbs part of it into the main peak.

Then integration. Where the baseline is drawn under a shoulder is a decision made by a person or by a piece of software configured by a person. It moves the number.

A point or two of spread between services on this assay is ordinary. Treating one lab as ground truth is how people end up in arguments with suppliers that neither side can win.

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comment on [PSA] milestone is not what most of this community thinks it is in c/progresspics · 30 points · 3 months ago

Did the clothes change before the number did for you too?

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comment on someone explain non-scale victory to me like I have not read a paper in years in c/progresspics · 1 points · 4 months ago

Nobody noticed for months.

Adding the thing I wish someone had said to me — the goal you picked at week one was a guess.

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comment on someone explain gradient to me like I have not read a paper in years in c/hplc · 17 points · 4 months ago

baseline choice is a decision, not a measurement

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comment on [Question] how do you actually verify purity in c/hplc · 179 points · 5 months ago

Area percent is the integrated area of your peak over the total integrated area at one wavelength on one gradient. Change any of those and the number changes without the sample changing.

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comment on [Meta] proposal — a flair for HPLC posts in c/hplc · -4 points · 6 months ago

UV response is not uniform across species. At 214nm you are looking at the peptide bond, which is why it is the working wavelength for this class; at 280nm you only see tryptophan, tyrosine and phenylalanine.

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comment on anyone else notice progress kicking in around week 89 in c/progresspics · 27 points · 6 months ago

Weighing under consistent conditions — same time, same state, same scale — removes most of the apparent variability people find distressing.

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comment on switched from 1.0mg to 2.4mg and nausea got better, not worse in c/progresspics · 1 points · 7 months ago

Correcting my own post above — that was week 35, not the week I wrote. Same story, wrong number.

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comment on switched from 1.0mg to 2.4mg and nausea got better, not worse in c/progresspics · 12 points · 7 months ago

Why this board is text only, since new members ask every week.

Adding the thing I wish someone had said to me — the goal you picked at week one was a guess.

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comment on switched from 1.0mg to 2.4mg and nausea got better, not worse in c/progresspics · 20 points · 7 months ago

Careful — that reads as advice about what someone else should do, and this board is for describing your own.

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comment on [Discussion] we are measuring HPLC at the wrong time and calling it noise in c/hplc · 104 points · 8 months ago

Small fix — 214nm, not 210. It matters for the comparison you are making with the other run.

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comment on what would you tell week-1 you about struggle in c/progresspics · 11 points · 8 months ago

Circumference measurements often continue changing during a scale plateau because composition changes are not visible on a bathroom scale.

cato_batista is right that the clothes tell you before the scale does.

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comment on [Discussion] the chromatogram advice in here is 2 years out of date in c/hplc · 58 points · 10 months ago

baseline choice is a decision, not a measurement

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comment on [Results] 39 weeks, 17kg, and progress was the hard part in c/progresspics · 418 points · 1 year ago

Why this board is text only, since new members ask every week.

A photograph invites comparison on things nobody can control — lighting, posture, where you carry weight, what you looked like before any of this. Text invites description of what changed for you: the jacket, the stairs, the measurement, the month it took.

The result is a board where the posts are about people’s actual experience rather than about images, and where nobody is competing on the wrong axis. It was a deliberate choice, it has been challenged periodically, and every time it has been kept.

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