u/andres_sorensen

Stopped at a low step because there was no reason to go further and no data to tell me what further would do.

Cosigning the escalation point. Almost every difficult report on this board is from somebody who went up quickly.

Asked SGN what volume they reconstitute to for their own stability testing and they answered in one line. Useful thing to know.

Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.

Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.

Small fix — a U-100 syringe is 100 units per mL. If yours is marked differently it is not U-100 and the whole calculation changes.

Spent 24 weeks confused about this until somebody drew the table for me. 10mg, 2mL, 5mg/mL, 0.75mg is 15 units. That is the whole thing.

small trial, big effect, wide error bars

The arithmetic in full: concentration is mass over volume, so 30mg into 1mL gives 30mg/mL. A U-100 syringe is graduated at 100 units per millilitre, so 1.5mg is 1.5 divided by 30 millilitres, which is 5 units.

The constipation profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.

Has anyone posted an independent test on this compound recently?

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

Yes. Writing 5mg/mL on the vial takes four seconds and removes the entire class of error this board exists to fix.