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Single comment threadYou are looking at one branch of genuine question about oral GLP-1 that I am slightly embarrassed to ask — 57 comments in the full submission. View in context.
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c/orforglipron·submitted 4 months ago by u/salma_almeida

genuine question about oral GLP-1 that I am slightly embarrassed to ask

Trial Databranch of 6 comments

genuine question about oral GLP-1 that I am slightly embarrassed to ask. I am not trying to be the "source?" guy. I would just like a source. Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve. Milligram comparisons…

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6 comments, started 4 months ago
u/lina_novak60 points·4 months ago

Are you comparing doses across a small molecule and a peptide?

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u/salma_almeidaOP40 points·4 months ago

do not assume reconstitution intuitions apply, there is nothing to reconstitute

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u/dilara_weiss41 points·4 months ago

Nothing containing this compound is approved by any regulator, and research-use-only material is not approved for human use.

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u/reship_roulette28 points·4 months ago

Small fix — the two programme names got swapped upthread and it changes which population the figure came from.

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[removed]18 points·4 months ago

[removed by moderator]

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u/trialwatch_theotrial nerd5 points·4 months ago

Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can be formulated as a conventional tablet.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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