[Lab] 6th independent test on SWB — 99.1% on a claimed 99.0%, and the trend is the interesting part
Short version of the title, which is already short: 6th independent test on SWB — 99.1% on a claimed 99.0%, and the trend is the interesting part. Longer version underneath. To save the first four comments: 99.1% and 99.0%. Daily rather than weekly sounds trivial until you think about what a missed dose means in each…
Why "oral" is doing two completely different jobs in the sentences people write here.
Oral semaglutide is a peptide co-formulated with an absorption enhancer, which is why it comes with food and water timing requirements. This compound is a non-peptide small molecule that activates the same receptor, formulated as an ordinary tablet.
The practical consequences differ enormously: no timing constraints, a conventional manufacturing route, different stability behaviour, and a different analytical problem for anybody trying to verify identity or purity. Whenever a thread here compares the two, check which sense of "oral" each half is using.
Which programme and which readout are you quoting?
a non-peptide agonist does not degrade the way a peptide does
the tolerability profile reads broadly similar to the class
daily dosing, not weekly, so the exposure profile is different
daily dosing changes adherence in both directions
Retitled to name the programme. It is what makes these threads findable in a year.
Read both programme names carefully after mixing them up in a comment and being politely corrected.
Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.
Small fix — the two programme names got swapped upthread and it changes which population the figure came from.