[Results] 70 weeks on 2.4mg, full numbers, ask me anything boring
Update, and the title has the headline: 70 weeks on 2.4mg, full numbers, ask me anything boring. 70 weeks and 2.4mg. Those are measured, not estimated, and not rounded up in my favour. What is actually known, and what is being assumed. Known: it is a small-molecule GLP-1 receptor agonist, dosed daily, with clinical…
It is a non-peptide small-molecule agonist at the GLP-1 receptor. That is a substantial medicinal chemistry achievement: getting a small molecule to activate a receptor evolved for a peptide ligand.
Corrected a cross-class dose comparison in the title. The body is untouched.
Correction: that is the oral peptide product, which is a different thing entirely. This one is a small molecule.
Milligram-for-milligram comparison with an injectable peptide is not meaningful and I should not have made it.
the boards keep comparing it to injectables at matched doses, which is meaningless
The no-timing-restriction thing is the part I would care about most in practice, and it barely gets mentioned here.
a non-peptide agonist does not degrade the way a peptide does