unpopular opinion: most of what gets said here about orforglipron is guesswork
unpopular opinion: most of what gets said here about orforglipron is guesswork. Making the case below, and I expect to lose some of it in the comments. Oral semaglutide is a peptide co-formulated with an absorption enhancer and carries food and water timing requirements. A small molecule does not have that…
Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.
Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.
yara_boateng is right that milligram comparisons across classes tell you nothing.
Corrected a cross-class dose comparison in the title. The body is untouched.
Small fix — the two programme names got swapped upthread and it changes which population the figure came from.
no food and water restrictions is the practical difference people care about