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c/orforglipron·submitted 1 months ago by u/certified_reference

help me understand oral GLP-1, I have read the wiki twice

Trial Databranch of 7 comments

Slightly embarrassed to be asking this, but: help me understand oral GLP-1, I have read the wiki twice. Holding off on any opinion until phase 3 reports. That is not a satisfying position and it is the honest one. The analytical point, which this board keeps getting wrong by importing habits from the peptide side.…

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7 comments, started 1 months ago
u/kenji_laurent14 points·1 months ago

It is a non-peptide small-molecule agonist at the GLP-1 receptor. That is a substantial medicinal chemistry achievement: getting a small molecule to activate a receptor evolved for a peptide ligand.

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u/ayesha_erdogan9 points·1 months ago

Same view. The analytical problem is different enough that the usual purity discussions here do not transfer cleanly.

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u/scam_taxonomyc/scamalerts11 points·1 months ago

no food and water restrictions is the practical difference people care about

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u/incretin_ivyMOD8 points·1 months ago

Retitled to name the programme. It is what makes these threads findable in a year.

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u/emil_marchand12 points·1 months ago

the boards keep comparing it to injectables at matched doses, which is meaningless

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u/fasting_insulin_f18 points·1 months ago

Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction.

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u/trialwatch_theotrial nerd2 points·1 months ago

Agreed — non-peptide is the fact that everything else follows from, including the manufacturing and the analytics.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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