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c/glp1science·submitted 1 year ago by u/laila_almeida

why does nobody talk about incretin

Speculationbranch of 6 comments

Slightly embarrassed to be asking this, but: why does nobody talk about incretin. Asked a question here that I thought was stupid and got three papers back. Best thread I have been in on this site. The GIP question, which is the most interesting unsettled thing in this field. Dual agonism at GIP and GLP-1 receptors…

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6 comments, started 1 year ago
u/gastric_emptying_gMOD99 points·1 year ago

Speculation is welcome here if it is labelled. This one has been relabelled rather than removed.

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u/nadia_fonseca-29 points·1 year ago

half-life is why these are weekly and not daily

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u/kavya_kravchenko60 points·1 year ago

Started reading limitations sections first. It has changed how much weight I give to almost everything posted here.

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u/laila_almeidaOP78 points·1 year ago

tolerance to the gastric effect develops, appetite effect largely persists

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u/laila_almeidaOP59 points·1 year ago

Correction: that is glucose-dependent insulin secretion, which is why hypoglycaemia risk is low as monotherapy. Not the same claim as you made.

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u/laila_almeidaOP19 points·1 year ago

dose response is not linear and nobody should assume it is

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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