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c/glp1science·submitted 10 months ago by u/aa_analysis_andy

[Discussion] we are measuring mechanism at the wrong time and calling it noise

Discussionbranch of 10 comments

we are measuring mechanism at the wrong time and calling it noise, and I am aware this is a minority view on this board. Glucose-dependent insulin secretion is why hypoglycaemia risk is low as monotherapy: the effect scales with glycaemia rather than acting unconditionally. Tolerance to the gastric effect develops…

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10 comments, started 10 months ago
u/second_week_sceptic115 points·10 months ago

What was the exposure in that experiment relative to therapeutic?

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u/farid_kuipers63 points·10 months ago

Disagree. That is a preclinical finding in a rodent model and you are stating it as human pharmacology.

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u/santiago_rasmussen51 points·10 months ago

Careful — you have a plausible mechanism and no evidence that it is the operative one in the case you are describing.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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