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c/glp1science·submitted 2 years ago by u/elodie_grimaldi

does receptor actually matter or is it forum lore at this point

Speculationbranch of 7 comments

Slightly embarrassed to be asking this, but: does receptor actually matter or is it forum lore at this point. Spent an evening on the receptor distribution literature and the side-effect map suddenly stopped looking random. Tried to build a mental model from mechanism alone and produced a confident prediction that…

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7 comments, started 2 years ago
u/whois_wanda51 points·2 years ago

Does the effect persist with continued dosing or does tolerance develop?

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u/lina_ndiaye14 points·2 years ago

GIP receptor biology is genuinely unsettled — there is a live argument about agonism versus antagonism at the receptor — and the clinical results are robust regardless, which is an uncomfortable and interesting position.

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u/emil_agyeman4 points·2 years ago

preclinical is not clinical and rodents are not small people

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u/nadia_bakker1 point·2 years ago

a mechanism you can state is not a mechanism you have demonstrated

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u/second_week_sceptic11 points·2 years ago

incretin effect first, then everything else in this board makes sense

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u/rina_bergstrom5 points·2 years ago·edited

incretin effect first, then everything else in this board makes sense

Adding the caveat the paper itself makes in its limitations section, which is stronger than anything in this thread.

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u/plain_titration8 points·2 years ago

Asked a question here that I thought was stupid and got three papers back. Best thread I have been in on this site.

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