does gastric emptying actually matter or is it forum lore at this point
Trying to get a straight answer on this: does gastric emptying actually matter or is it forum lore at this point. Why mechanism talk keeps misleading people, including me. A mechanism tells you a direction. It does not tell you a magnitude, a timescale, or whether the pathway is operative at the exposures involved.…
Long half-life in this class comes from structural modification that promotes albumin binding and resists enzymatic degradation. Weekly dosing is a consequence of the molecule, not a convenience decision.
What does the discussion section say about the limitation you are glossing?
the peripheral and central stories are not in competition
Spent an evening on the receptor distribution literature and the side-effect map suddenly stopped looking random.
Disagree. That is a preclinical finding in a rodent model and you are stating it as human pharmacology.
The half-life explanation was the thing that made weekly dosing intuitive for me rather than arbitrary.