the half-life thing finally clicked for me and I want to write it down
the half-life thing finally clicked for me and I want to write it down. Not a hot take, just something I have not seen said plainly here. Started reading limitations sections first. It has changed how much weight I give to almost everything posted here. The half-life explanation was the thing that made weekly dosing…
I would not read that in vitro number across to a person. The conditions are nothing like physiological.
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That study was in a rodent model. Worth stating, since the thread has been reading it as human data.
albumin binding is most of the half-life story
I would not read that in vitro number across to a person.
This is the concept everything else on this board is downstream of.
Small fix — it slows gastric emptying, it does not halt it, and the distinction matters for the mechanism you are proposing.