[Meta] proposal — a flair for half-life posts
Putting this to the board: proposal — a flair for half-life posts. Why mechanism talk keeps misleading people, including me. A mechanism tells you a direction. It does not tell you a magnitude, a timescale, or whether the pathway is operative at the exposures involved. "Receptor X is expressed in tissue Y" is a fact;…
Receptor expression in a tissue is necessary but not sufficient for an effect. You also need the agonist to reach it at relevant exposure, and that is where a lot of confident mechanism talk falls down.
Correction: that is glucose-dependent insulin secretion, which is why hypoglycaemia risk is low as monotherapy. Not the same claim as you made.
Receptor expression in a tissue is necessary but not sufficient for an effect.
Agreed — and it is why the central and peripheral stories are complementary rather than rival.
That study was in a rodent model. Worth stating, since the thread has been reading it as human data.
Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.
mechanism explains a direction, not a magnitude
The half-life explanation was the thing that made weekly dosing intuitive for me rather than arbitrary.