why does nobody talk about appetite
Genuine question, and the title is the question: why does nobody talk about appetite. Spent an evening on the receptor distribution literature and the side-effect map suddenly stopped looking random. Read the primary paper after arguing about the summary for a fortnight. The discussion section said almost the…
Tolerance to the gastric effect develops with continued exposure while the appetite effect largely persists. That single fact explains most of the "it settles but it still works" pattern the side-effect board reports.
a mechanism you can state is not a mechanism you have demonstrated
half-life is why these are weekly and not daily
preclinical is not clinical and rodents are not small people
preclinical is not clinical and rodents are not small people
Adding the caveat the paper itself makes in its limitations section, which is stronger than anything in this thread.
Left up and flaired Explainer. This is the standard of post the board was created for.
dose response is not linear and nobody should assume it is