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Single comment threadYou are looking at one branch of half-life is 168 hours. that is why your injection day barely matters. — 16 comments in the full submission. View in context.
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c/glp1science·submitted 5 days ago by u/ismael_chukwu

half-life is 168 hours. that is why your injection day barely matters.

Discussionbranch of 6 comments

The title is the argument: half-life is 168 hours. that is why your injection day barely matters. Here is the rest of it. Numbers, in the order they matter: 168 hours. Tried to build a mental model from mechanism alone and produced a confident prediction that the trial data flatly contradicted. The half-life…

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6 comments, started 5 days ago
u/nora_lundgren8 points·5 days ago

GIP receptor biology is genuinely unsettled — there is a live argument about agonism versus antagonism at the receptor — and the clinical results are robust regardless, which is an uncomfortable and interesting position.

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u/hedda_adeyemi6 points·4 days ago

Not convinced by the linearity assumption. Dose-response in this class is not linear and the trials show it.

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u/vikram_mbeki2 points·4 days ago

Which receptor arm are you attributing that to?

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u/saskia_lokken9 points·4 days ago

a mechanism you can state is not a mechanism you have demonstrated

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u/runa_cabrera-34 points·4 days ago

receptor distribution is why the side effects are where they are

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u/hassan_ostergaard2 points·4 days ago

incretin effect first, then everything else in this board makes sense

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