6.3k
why does nobody talk about Zepbound
Asking properly rather than in a comment on somebody else’s thread: why does nobody talk about Zepbound. Vials and pens carry the same molecule; what differs is fill…
u/santiago_villalobos
Contributes reviews on supplier material. Based in Catania.
member · joined 11 Feb 2025
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Overview — page 2 of 2
comment on why does nobody talk about Zepbound in c/tirzepatide · 179 points · 1 year ago
2.5 is the starter dose and it is not meant to be the dose that works
comment on [Discussion] chromatogram is doing more work than we give it credit for in c/hplc · 1 points · 1 year ago
integration decisions move the number more than the sample does
comment on [Discussion] chromatogram is doing more work than we give it credit for in c/hplc · 6 points · 1 year ago
Do you have the mass, or only the UV trace?
5.1k
[Discussion] chromatogram is doing more work than we give it credit for
chromatogram is doing more work than we give it credit for — a position I have arrived at slowly and would like tested. A shoulder that does not baseline-resolve cannot…
comment on hepatic fat — 19 things I got wrong before I got it right in c/survodutide · 73 points · 1 year ago
Careful with the mechanism claim. Glucagon agonism is plausible as an explanation and it has not been isolated as the operative one.
comment on [Lab] MKM cagri — Medutest came back 97.2% against a claimed 97.0% in c/hplc · 5 points · 1 year ago
report the method or do not report the number
comment on [Discussion] ATTAIN is doing more work than we give it credit for in c/orforglipron · 1 points · 1 year ago
Careful — purity methods for peptides do not read across to a small molecule and the numbers are not equivalent.
comment on how much of what we believe about HPLC actually comes from method development threads in c/hplc · 179 points · 1 year ago
Resolution between two peaks depends on retention, selectivity and efficiency. A shallower gradient buys retention and usually resolution, at the cost of peak width and run time.
comment on [Lab] CPC orfo — Janoshik came back 98.2% against a claimed 97.5% in c/orforglipron · 11 points · 1 year ago
Disagree. You are comparing doses across a small molecule and a peptide, which is not a comparison of anything.
comment on glucagon is the most under-discussed thing on this board in c/survodutide · 115 points · 1 year ago
Phase 2 in a biopsy-confirmed population is a demanding design: recruitment is slow, the population is specific, and the results do not generalise to people who have not been characterised that way.
comment on [Meta] the SURPASS rule is doing its job and people should stop complaining in c/tirzepatide · 37 points · 2 years ago
the appetite effect is blunter than sema, in a good way, most weeks
comment on [Lab] 22th independent test on WXT — 99.2% on a claimed 98.5%, and the trend is the interesting part in c/tirzepatide · 8 points · 2 years ago
sulphur burps are the signature complaint and they are not dangerous
comment on why does nobody talk about biopsy in c/survodutide · 60 points · 2 years ago
Is that a weight number from a different programme?
comment on am I the only one who found Zepbound harder than the injections in c/tirzepatide · 34 points · 2 years ago
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
comment on [Lab] 16th independent test on ERP — 97.4% on a claimed 97.0%, and the trend is the interesting part in c/hplc · 62 points · 2 years ago
Small fix — 214nm, not 210. It matters for the comparison you are making with the other run.
comment on [Lab] KP cagri — VendorInvestigate came back 98.1% against a claimed 97.5% in c/hplc · 1 points · 2 years ago
you cannot report to two decimals off that baseline
comment on unpopular opinion: most of what gets said here about GIP is guesswork in c/tirzepatide · 1 points · 2 years ago
Did you come to this from sema, and if so how long was the gap?
comment on chromatogram is the most under-discussed thing on this board in c/hplc · 21 points · 2 years ago
That is area percent, not mass percent. The trace cannot give you the second one.
comment on [Lab] 18th independent test on SWB — 99.4% on a claimed 99.0%, and the trend is the interesting part in c/hplc · 241 points · 2 years ago
A shoulder that does not baseline-resolve cannot be quantified honestly. You can report it as an unresolved shoulder, which is useful information, or you can develop the method until it resolves.
comment on [Meta] the method development rule is doing its job and people should stop complaining in c/hplc · 1 points · 2 years ago
What wavelength, and what was the gradient?
comment on [Meta] the method development rule is doing its job and people should stop complaining in c/hplc · 1 points · 2 years ago
Small fix — 214nm, not 210. It matters for the comparison you are making with the other run.
7.1k
[Meta] the method development rule is doing its job and people should stop complaining
the method development rule is doing its job and people should stop complaining. Disagreement welcome, but bring a concrete alternative wording. Why two honest labs…
comment on how much of what we believe about HPLC actually comes from gradient threads in c/hplc · 20 points · 2 years ago
LC-MS for identity, UV for relative quantity
comment on gradient — 17 things I got wrong before I got it right in c/hplc · 12 points · 2 years ago
system suitability before you believe any number on the run