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RE

u/receptor_bias_rick

Biased agonism is real and mostly irrelevant to your dose. Mostly.

member · joined 19 Aug 2024

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Comments — page 2 of 2

comment on [PSA] telehealth is not what most of this community thinks it is in c/compounding · 89 points · 1 year ago

Disagreeing with this bit: registration is not equivalence, and the two get run together constantly.

This is the distinction the whole board runs on. Everything else follows from it.

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comment on someone explain state board to me like I have not read a paper in years in c/compounding · 76 points · 1 year ago

do not assume the concentration matches the branded product

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comment on how much of what we believe about batch actually comes from purity threads in c/coa · 164 points · 1 year ago

Disagree that a lower number is automatically worse. A conservative claim that survives testing is worth more than an optimistic one that does not.

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comment on am I the only one who found struggle harder than the injections in c/progresspics · 6 points · 1 year ago

measurements beat photographs for actually tracking anything

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comment on how much of what we believe about batch actually comes from related substances threads in c/coa · 0 points · 2 years ago

Net peptide content is the fraction of the powder that is actually peptide once counterion, water and residual solvent are accounted for. A 99% pure acetate salt can still be about 85% peptide by mass.

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comment on SELECT: what the trials say vs what this community says in c/trialwatch · -23 points · 2 years ago

On means, which this board treats as targets and which are nothing of the sort.

A reported mean body weight change is the centre of a distribution that in these trials is very wide. Substantial numbers of participants did much better, and substantial numbers did considerably worse while remaining on the drug and in the analysis.

Quoting the mean as an expectation therefore misleads in both directions: it makes ordinary results look like failures and it makes exceptional results look normal. If a paper publishes the distribution — and several do, in the appendix — look at that instead. It is far more informative than the number in the abstract.

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comment on unpopular opinion: most of what gets said here about water content is guesswork in c/coa · 157 points · 2 years ago

Area percent is the peak area of your compound over the total integrated area, at one wavelength, on one gradient.

zaid_balogun has the distinction right — one is a fraction of the detector signal, the other is a fraction of the mass.

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comment on [Discussion] the 503A advice in here is 2 years out of date in c/compounding · 15 points · 2 years ago

do not assume the concentration matches the branded product

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comment on [Lab] 16th independent test on WXT — 99.3% on a claimed 98.5%, and the trend is the interesting part in c/coa · 13 points · 2 years ago

Did you ask for the batch-specific document, or is this the catalogue one?

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comment on [Discussion] the area percent advice in here is 2 years out of date in c/coa · 32 points · 2 years ago

Same view. WWB prints the column and the gradient, which means somebody could actually reproduce the run.

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